Meta-analysis of Dolphin and Human Peripheral Blood Mononuclear Cells Reveals Inflammatory Signatures Associated with Exposure to High Levels of Perfluoroalkyl Substances
Currently a fundamental gap exists on how persistent organic pollutants affect humans especially those who consume high levels of seafood from contaminated coastal waters. There is an urgent need to betterunderstand effects of these contaminants on human health in coastal communities. Elevated contaminant levels in coastal seafood will give rise to increased contaminant burdens in humans who consume coastal seafood and given the toxicity of these contaminants increase risk for immune system disorders. In thispaper we describe how we assessed the effects of contaminant exposures using high-throughput RNA sequencing (RNA-seq) in peripheral blood mononuclear cells from two species, dolphins and humans. This paper presents an integrated systems biology approach to understand the adverse effects of one of these CECs PFAS on both species.
Index Terms - One Health, PFASs, PBDEs, PBMC, Systems Biology.