Synthesis of Hydrogenated Isozonarol via Diels Alder Reaction: A Convergent Approach to ABC Tricyclic Core of Marine Sesquiterpenoids
The synthesis of natural products plays an important role in organic and biological chemistry. These compounds show a great variety of chemical structures and a wide range of biological activities1. The synthetic utility and potential power of the Diels–Alder reaction2 in organic chemistry is evident. The present paper relates to the synthesis of dihydroisozonarol by [4+2] cycloaddition reaction between 1,3,3-trimethyl-2-vinyl-1-cyclohexene and (E)-1-(2,5-dimethoxyphenyl) but-2-en-1-one followed by hydrogenation and demethylation.
Keywords - Sesquiterpenoids, Cylcoaddition, Diels Alder reaction