Paper Title
Role of The Variant Gly82ser of The Rage Gene in The Stroke in Tunisian Patients

Abstract
Background - Stroke is a multifactorial disorder influenced by environmental and genetic factors.The receptor for advanced glycosylation end products (RAGE), a member of the immunoglobulin superfamily of cell surface molecules has been reported to be involved in a variety of neurological diseases. This study examined the influence of Gly82Ser variant of the RAGE gene on the risk of stroke by the PCR-RFLP method in a sample of Tunisian patients. Results: The study included 205 Tunisian patients with stroke and 180 control subjects.The genotype frequencies (GG, GS, SS) were significantly different (p<0.005) between the ischemic stroke (15.4%; 46.1%; 38.5%) and control groups (39.4%; 54.5%; 6.1%) in the Tunisian population. In addition, the odds ratio showed that the genotype SS is a risk factor for the stroke in the co-dominant model (OR=6.2 [2.46-7.24] p<0.004) and the dominant model (OR=3.57 [1.10-2.77] p<0.05). In conclusion, this study suggested that the Gly82Ser polymorphism of the RAGE gene is associated with the risk of stroke in the Tunisian population. Keywords - Gly82Ser polymorphism, RAGE, Stroke.