Paper Title
Impact Of Metformin On Talc And Streptozotocin Induced Diabetes In Wistar Rats

Abstract
Diabetes is initiated by the modulations in insulin secretion or sensitivity and indicated by several blood markers. Talc is an extensively used additive in the pharmaceutical industry as an integral components of many drug formulations. We, previously reported the diabetes induction by long term application of talc. The present study compares pharmacological effects of metformin on talc and streptozotocin (STZ) induced diabetes in albino Wistar rats. Diabetes was induced by the single dose of STZ (45 mg/kg) and talc 0.14mg/kg per kg of body weight administered orally for the period of 20 weeks. Application of STZ and talc altered the diabetes, its associated liver and kidney damage markers including blood glucose, insulin, triglyceride, HbA1c, liver glycogen, urea, uric acid, ALP, ALT, AST, creatinine and bilirubin. Histopathological studies have shown similar damaging effects of both talc and STZ on pancreatic beta cells. Similar impact of metformin was found on majority of diabetic parameters induced by two different substances (talc and STZ) suggesting a similar mechanism of diabetes induction. Keywords: Talc, STZ, Metformin, Diabetes, Wistar Rats, Blood Parameters