Paper Title
Photo Thermal Ablation Against Cancer Using Nir-Absorbing Polyaniline-Grafted Glycochitosan

Abstract
Nanoparticle-assisted thermal ablation therapy has become a potential cancer treatment recently. This work presents an amphiphilic polymer composed of glycol chitosan that contains polyaniline side chains (PANI-GCS). The hydrophobic PANI is covalently grafted on the hydrophilic GCS via its highly reactive amine groups to form an amphiphilic polymer, which could self-assemble into nanoparticles (NPs) in an aqueous milieu. The conjugated PANI can be utilized as nanoscale heat sources, remotely controlled by using near-infrared (NIR) light, for cancer cell ablation. The in vitro results show that that treatment with PANI-GCS NPs had a negligible effect on the viability of murine mammary tumor cells. Additionally, antitumor efficacy of PANI-GCS NPs upon NIR irradiation is evaluated using a mouse subcutaneous tumor model. The in vivo results reveal that treatment with localized heat resulted in the suppression of tumor growth. Together, these analytical results suggest that PANI-GCS NPs may serve as a platform for hyperthermia for effective cancer treatment. Index Terms - Cancer therapy; photothermal agent;conducting polymer; chitosan;nanoparticles