Paper Title
Determination of Acute Phase Protein Levels in Cattle with Paratuberculosis

Abstract
Aim - Paratuberculosis leads to economic losses due to loses body weight, decrease in milk yield and fertility problems. Diagnosis of this disease is of great importance for both economic and public health. However, there is a definite method for the diagnosis of this disease. In this study, serologically in tagged paratuberculosis in cattle detection of acute phase proteins from serum haptoglobin (Hp) , Serum amyloid-A (SAA), ceruloplasmin (Cp), C-reactive protein (CRP), albümin (alb) and total protein (TP) is intended to identify changes in the level. Material and Method: In study, 30 paratuberculosis positive cattle formed test group and 30 healthy cattle formed control group. Serologically diagnosis for paratuberculosis used ELISA (IDEXX Paratuberculosis screenging ab test). SAA, Hp, CRP, Cp, albumin and Tp of acute phase proteins level were measured for each blood sample for all of groups. Results: All analysis of results showed that SAA (p<0.001), Hp (p<0.001), CRP (p<0.01) ve Cp (p<0.001) level was higher in cattle with paratuberculosis than in healthy cattle. The significant decreaase in the levels of total protein and albümin in cattle with paratuberculosis (p<0.001). Conclusion: While in cattle with paratuberculosis an increase in the levels of acute phase proteins such as serum SAA, Hp, CRP and Cp was showed, albümin and total protein levels decreased. It was considered that the measurement of acute phase proteins was useful in the evaluation of health in cows. Keywords - Acute phase protein; bovine; Mycobacterium paratuberculosis; paratuberculosis We would like to thank University of Ondokuz Mayis BAP for support . It was summary from the master thesis.