Paper Title
A Systematic Literature Review of Diabetes-Specific Quality of Life in ASEAN

Abstract
Introduction: Diabetes mellitus is notorious for its metabolic effect, acute and long-term complications and impact on Health-related Quality of Life (HRQoL). Objective: The current systematic review was conducted to ascertain (1) the latest available information about HRQoL, (2) to discover the main methodological flaws in the studies of HRQoL, and (3) the main factors associated with HRQoL in people with diabetes. Methods: National and international databases (Y hoc Thanh Pho Ho Chi Minh, Vietnam Journal of Preventive Medicine, Journal of Practical Medicine, Pubmed, Medline, Web of Science, CINAHL, Scopus, PsycINFO, ERIC, Google and Google Scholar) were searched following search terms: “diabetes”, “quality of life”, “đái tháo đường” and “chất lượng cuộc sống”. The data analysed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of 36 studies passed the inclusion criteria and were included in the review. The included studies were as follows: 18 studies from Malaysia, 9 studies from Singapore, 6 studies from Indonesia, 2 studies from Thailand, one study from Vietnam. Most studies investigated HRQoL among people with type 2 diabetes mellitus and17 different instruments were used in the studies. Conclusion: The growing interests over the last decade in evaluating HRQoL among people with diabetes were observed in ASEAN. The findings of this review showed that people with diabetes had a lower HRQoL than healthy people. The findings also indicated that better socioeconomic status, better control of risk factors and complications were associated with a better HRQoL among the patients with diabetes. Moreover, treatment adherence improved HRQoL. The reviewed studies suffered from major methodological and reporting flaws which limited the validity and generalization of their findings. Key words: Diabetes, quality of life, ASEAN, systemic literature review