Paper Title
Potential Protective Mechanism Of Crocin Against Amyloid Fibril Formation Of E46k Α-Synuclein In Parkinson Disease

Abstract
The E46K mutation of the α-synuclein gene has been linked to autosomal dominant early-onset of PD. Crocin is a carotenoid chemical compound of saffron that has been shown antioxidant and neural protective activity. This study examined the effect of Crocin in preventing the amyloid fibril in the E46K α-synuclein, through in vitro studies and computational simulations. These results support that Crocin is a potent inhibitor of E46K α-synuclein fibrillization and it could be considered as a potential therapeutic agent in the treatment of Parkinson disease. Index Terms - Crocin, E46K α-Synuclein, Amyloid, Protection.