Theoretical Study of the Alzheimer Drug Posiphen by Molecular Modeling Methods
Neurodegenerative diseases comprise one of the major public health concerns in our aging population. Alzheimer’s disease (AD) is the case, the most common form of dementia, is a degenerative disorder of the brain that leads to memory loss. The accumulation of β-amyloid is the most important factor for this disease. Our work propose theoretical study the inhibition of β-secretase enzyme wich is responsible from the accumulation of the β-amyloid by molecules serie supposed a based for posiphen as remedy of the Alzheimer disease.
Key words - Alzheimer disease, posiphen drugs, molecular modeling methods.