Combination Treatment Comprising Thermal Therapy And Chemoterapyusing Gold Nanorods
Combinatory treatment comprising thermal therapy and chemotherapy offers synergistic effects by inducing localized heat to targeted tumor sites and delivering anticancer drugs simultaneously to minimize systemic side effects and enhance the cytotoxic effect.In this study, we developed a novel platform for combining photothermal therapy and chemotherapy using drug-conjugated gold nanorods (GNRs). Camptothecin (CPT), a model anticancer drug, was chemically conjugated onto GNRs through hydrolytic ester bonding. Upon near-infrared (NIR) irradiation,localized heat from GNRs in target areas starts destroying tissues and cells via photothermal therapyand the elevated temperature accelerates hydrolysis of ester linkage, rapidly releasing drugs for chemotherapy. This combined NIR triggered thermal therapy and chemotherapy with CPT-functionalized GNRs (CPT-GNRs) presentsa synergistic effect that has high efficacy in in vitro tests, thus providing a versatile platform for efficient cancer treatments.