The Role of Microalgae in Cancer Therapy
Introduction: Utilizing microalgae in cancer therapy has been recently drawn special attention. They are enriched from polyunsaturated fatty acids (PUFAs) which can increase fluidity of cell membrane. Moreover existence of a pigment in microalgae called Fucoxanthin (Fuco) possessing antiproliferative, cytotoxic features as well as enhancing gap junction communications, scale the therapeutic importance up. Below the use of microalgae in cancer therapy will be explained.
Method: PUFAs derived from microalgae are employed in structure of a targeted liposome membrane coated by polyethylene glycol. On the other hand, the pigment of Fuco and given anticancer drug are incorporated into liposome. Due to high fluidity of liposome membrane, the great amount of drug can be transported into cancerous cell. Meanwhile Fuco can have either therapeutic role owing to cytotoxic property and contribute to effectiveness of the interest drug by enhancing intercellular communications. Furthermore, being antiangiogenic, Fuco can reduce tumor growth.
Result: Besides of PUFAs and Fuco pigment are derived from a natural resource, they can accelerate the speed of therapy by multiple features. Interestingly, PUFAs of microalgae are more stable than ones from other resources such as fish.Conclusion: Microalgae can be regarded as a prospering method in cancer therapy in near future. However more considerations should be done in clinical field.
Key words- polyunsaturated fatty acids, Fucoxanthin, microalgae, cancer therapy, liposome.