Paper Title
Sensitivity of Hepatocytes Isolated from Liver Mouse to Scorpion Venom, Involvement of COX2 in Oxidative Disturbance

Abstract
The main target of the neurotoxins of scorpion venom is the ion channels expressed on the excitable cells. Actually new purified components from these venoms seem to have another activity and their use as tools in therapeutic is in progress. This study was undertaken to investigate the effect of the whole Androctonus australis hector (Aah) venom on hepatocytes and the involvement of COX1 and COX2. Obtained results showed that Aah venom is able to disturb the oxidative balance and to induce a decrease of NO and GSH levels associated to an increase of MDA level and catalase activity. The use of COX2 antagonist (celecoxib) seems to restores the unbalance induced by Aah venom, however COX1antagonist (diclofénac) seems to have no effect. Androctonus australis hector venom seems to contain bioactive components which are active on the not excitable cells such as hepatocytes. The identification of these components from this venom could be of interest. Keywords - Aah Venom, Hepatocyte, Oxidative Stress