Paper Title
Theoretical Calculations, Biological Activities, Anion Sensing Applications and Crystallographic Studies of (E)-2-((3,5-Bis (Trifluoromethyl) Phenylimino) Methyl)-4,6-Dimethoxyphenol

Abstract
We report the synthesis of (E)-2-((3,5-bistrifluoromethyl)phenylimino)methyl)-4,6-dimethoxyphenol from the reaction of 3,5-bismethoxysalicylaldehyde with 3,5-bistrifluoromethylaniline.The molecular structure of the title compound was experimentally determined using X-ray single-crystal data and was compared to the structure predicted by theoretical calculations using density functional theory (DFT). In addition, nonlinear optical (NLO) effects of the title compound was predicted using DFT. Theoretical and UV-VIS spectroscopy studies of the interactions between the title compound and calf thymus DNA (CT-DNA)showed that the title compound interacts with CT-DNA. The colorimetric response of the title compound in DMSO to the addition of equivalent amount of anions (F-, CN-, H2PO4-, OH-, Br-, I-, SCN-, ClO4-, HSO4- N3- and AcO-) was investigated. This study is supported by a grant (Project Number: T�BİTAK 115F253) from the Scientific and Technical Research Council of Turkey. Keywords- Density Functional Theory, 3,5-Bismethoxysalicylaldehyde, X-ray Crystallography, Calf Thymus-DNA.