Paper Title
Bioactive Secondary Metabolites From an Endophytic Fungus Fusarium Oxysporum

Abstract
In recent years, researchers have begun to realize that plants may serve as a repository of untold numbers of organisms known as endophytes. Most endophytes are capable of synthesizing bioactive compounds that may provide plants with a defense against pathogens and some of these compounds have proven useful for novel drug discovery. An endophytic fungus named Fusarium oxysporum was isolated from the plant Aglaonema hookerianum Schott (Family: Araceae), followed by its large scale cultivation and extraction. Three compounds were isolated from the ethyl acetate extract of Fusarium oxysporum by using repeated chromatographic techniques. The structures of the isolated compounds were elucidated as 3β, 5α-dihydroxy-ergosta-7, 22-dien-6-one (1), 3β, 5α, 9α-trihydroxy-ergosta-7, 22-dien-6-one (2) and 4-hydroxy benzaldehyde (3) by extensive spectroscopic studies (1H NMR and 13C NMR). The crude extract was subjected to various bioassays (antioxidant and antimicrobial) and in some cases significant activities were observed. Keywords� Fusarium oxysporum, 3β, 5α-dihydroxy-ergosta-7, 22-dien-6-one ,4-hydroxy benzaldehyde, antioxidant, antimicrobial.