Paper Title
Targeted Delivery of Protease-Activated Receptor 1(Par 1)-Sirna By Carbonite Apatite Nanoparticles Suppresses Breast Cancer Growth

Abstract
Targeted therapies are among the most promising new agents for the treatment of breast cancer. It provides a novel method for the prevention and treatment of breast cancer, but the clinical application of targeted therapy is restricted, mainly because of the absence of an efficient and safe gene delivery system. In this study we used biocompatible inorganic carbonite apatite nanoparticles to deliver siRNA against PAR1 in vitro. The therapeutic efficiency of the treated groups was compared with the groups treated with anticancer drugs. Our findings suggest that carbonite apatite nanoparticles coated with siRNAs alone and in combination, hold promise as an effective therapy for the treatment of breast cancer. Keywords- Targeted therapy, siRNAs, PAR1, Carbonate apatite nanoparticles