Paper Title
The Correlation of Sema3b Level Between Maternal Serum and Placenta in Preeclampsia

Abstract
INTRODUCTION: Semaphorin3B (SEMA3B) is an antiangiogenic protein which expressed in placental tissue. Preeclampsia is a disease syndrome which characterized by hypertension and proteinuria presents after 20th weeks of gestation or immediately after delivery. SEMA3B was found to increase in placental tissue and maternal serum in PE. The aim of this study was to know the correlation between SEMA3B level in serum maternal and placental tissue in PE patients. METHOD: This is a cross-sectional study using analytical observation with 70 samples of PE patients. SEMA3B levels in serum and placental were examined using the ELISA method. The Spearman test was used to determine the correlation. P-values <0.05 were considered statistically significant. RESULTS: The results showed that there was a very significant correlation between the increase of SEMA3B levels in maternal serum and the increase of SEMA3B in placenta in PE (R=0.462, p-value=0.000). CONCLUSION: The SEMA3B level in maternal serum increases together with the SEMA3B levels in placenta in PE patients. Further studies are needed to confirm the results of this study.