Adme-Tox Profiles of the Most Commonly used Phthalates
Within this study we have used a few computational methods to investigate the toxicity and biological effects on humans of the most commonly used phthalates. The obtained results revealed that phthalates are a class of compounds reflecting high toxicity both when ingested and when inhaled, but by inhalation their toxicity is even greater. Phthalates may interact with important molecular targets in human organism disrupting their physiological activity: membrane receptors, kinases, phosphatases, transcription factors, transporters and other enzymes. These interactions conduct to predicted harmful effects of phthalates: toxicity and irritations of the respiratory and gastrointestinal tracts, dyspnea, skin and eye irritations and disruption of the functions of liver and of the reproductive system, these predictions being in good accord with clinical data concerning the observed effects of some phthalates in cases of acute exposures. Many of investigated phthalates are predicted to be able to inhibit some of the cytochromes involved in the metabolism of numerous drugs and consequently to affect the efficiency of administrated treatments for many diseases and to intensify the adverse drugs reactions.
Keywords - phthalates; ADME-Tox, pharmacokinetics, biological effects, toxicological effects